Chronic lymphatic leukaemia is the most common leukaemia in adults in Western countries, and has a highly heterogeneous clinical presentation and evolution. The mechanisms that cause the disease are not well known. Knowledge of the human genome and the development of new DNA sequencing technologies have enabled us to study in depth genetic alterations of tumours. Recently, the Spanish consortium for the study of the genome of this leukaemia has been established; it includes multidisciplinary groups that will facilitate a global study of the disease from epidemiology and the clinical sphere to molecular biology and bioinformatics.
Studies of the first genomes have demonstrated the complexity of this leukaemia, which has a great diversity of mutated genes, though these seem to suggest that a relatively limited number of mechanisms are involved in their development. This information also offers new targets for the development of innovative treatments.
Cycle: Challenges of the 21st Century, IV the Voice of Medicine, I
Organized by: Residence for Researchers, Fundació Clínic Barcelona, Institut Biomèdiques August Pi i Sunyer, Resa
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